Gupta P D
Manipal University, India
Title: Chronotherapeutically active formulations of valsartan to treat early morning surge in blood pressure
Biography
Biography: Gupta P D
Abstract
In the majority of hypertensive individuals, blood pressure (BP) rises in the early morning hours which lead to serious cardiovascular complications. Currently, available medicines will not meet the blood plasma level of the drug during the morning surge. Chronotherapeutically active formulations rely on unique technologies to deliver a proportion of the daily dose to the time of day when BP rises to peak or near peak levels. The purpose of this study was to develop programmed release dosage forms of valsartan for controlled delivery. The compression coated tablets of valsartan were developed using guar and xanthan gum as coating polymers and studied for physical characteristics, erosion study, in vitro release, ex vivo continuous dissolution absorption and stability study in rabbits. Compression coated tablets with guar gum-lactose (15:85), and xanthan gum: lactose (50:50) showed optimum lag time of 7±0.5 h, 6±0.5 h lag time respectively and shelf lives of the formulations were about 2 years. Absorption of the valsartan from marketed tablet was rapid, whereas absorption was delayed in the developed formulations with clear lag time which was the desired objective of the developed formulation. The optimized formulations showed improved bioavailability and pharmacokinetic profile in rabbits. Thus the present formulation provides therapeutic dosage of valsartan in the morning hours.